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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11710 | JAK-IN-5 | JAK | |
JAK-IN-5 is a JAK inhibitor. | |||
T11710L | JAK-IN-5 hydrochloride | JAK-IN-5 hydrochloride(2096999-92-5 Free base) | JAK |
JAK-IN-5 hydrochloride is a JAK inhibitor [1]. | |||
T11704 | JAK-IN-3 | CCR | |
JAK-IN-3 is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively. | |||
T63086 | SYK/JAK-IN-1 | ||
SYK/JAK-IN-1 is a dual SYK/JAK inhibitor with IC50 values of less than 5 nM for both SYK and JAK2. | |||
T63581 | JAK-IN-20 | ||
JAK-IN-20 is a potent, orally active, broad-based JAK inhibitor, capable of acting on JAK1 (IC50: 7 nM), JAK2 (IC50: 5 nM), and JAK3 (IC50: 14 nM).JAK-IN-20 has excellent pharmacokinetic and anti-inflammatory activity in... | |||
T9764 | JAK-IN-14 | ||
JAK-IN-14 is a potent and selective JAK1 inhibitor, with an IC 50 of <5 μM. JAK-IN-14 is more than 8-fold selective for JAK1 than JAK2 and JAK3 [1]. | |||
T74800 | HAT-SIL-TG-1&AT | ||
HAT-SIL-TG-1&AT, a hypoxia-activated prodrug, functions as a Janus tyrosine kinase (JAK) inhibitor demonstrating antitumor effects by inhibiting JAK-STAT signaling within tumor tissues. It also suppresses the proliferati... | |||
T75535 | 5-epi-Arvestonate A | ||
5-epi-Arvestonate A, a sesquiterpenoid extracted from Seriphidium transiliense whole plants, enhances melanogenic production by stimulating MITF and tyrosinase family gene transcription. Additionally, it suppresses IFN-γ... | |||
T73558 | W1131 | ||
W1131, a potent STAT3 inhibitor, effectively triggers ferroptosis and suppresses cancer progression across various models including gastric cancer cell subcutaneous xenograft, organoids, and patient-derived xenograft (PD... | |||
T80847 | W1131 TFA | STAT | |
W1131 TFA is a potent STAT3 inhibitor inducing ferroptosis, effectively halting cancer progression in subcutaneous xenograft, organoid, and PDX models of gastric cancer. Besides mitigating chemoresistance to 5-FU in canc... |